Publications
2024
- Deep learning-based classification of erosion, synovitis and osteitis in hand MRI of patients with inflammatory arthritisMaja Schlereth, Melek Yalcin Mutlu, Jonas Utz, Sara Bayat, Tobias Heimann, Jingna Qiu, Chris Ehring, Chang Liu, Michael Uder, Arnd Kleyer, Frank Roemer, Georg Schett, Katharina Breininger and Filippo Fagnidoi: 10.1136/ rmdopen-2024-004273 | RMD Open 2024;10:e004273. June 17, 2024.
- Anatomical pattern of entheseal and synovial fibroblast activation in patients with psoriasis and its risk of developing psoriatic arthritisGiulia Corte, Armin Atzinger, Selahattin Alp Temiz, Rita Noversa de Sousa, Melek Yalcin Mutlu, Verena Schoenau, Maria Gabriella Raimondo, Arnd Kleyer, Torsten Kuwert, Andreas Ramming, David Simon, Michael Sticherling, Christian Schmidkonz, Georg Schett and Filippo Fagnidoi: 10.1136/rmdopen-2024-004294 | RMD Open 2024;10:e004294. June 11, 2024.
- Unveiling Metabolic Similarities of Entheses in Patients with Psoriasis and Psoriatic Arthritis Using Noninvasive In Vivo Molecular Imaging: Results From a Cross-sectional Exploratory StudyFilippo Fagni, Koray Tascilar, Rita Noversa de Sousa, Sara Bayat, Lukas Sollfrank, Arnd Kleyer, Michael Sticherling, Adrian P. Regensburger, Ferdinand Knieling, Markus F. Neurath, Georg Schett, Maximilian Waldner, David Simondoi: 10.1002/art.42917 | Arthritis & Rheumatology, 15 May 2024
- Using Polygenic Risk Scores to Aid Diagnosis of Patients With Early Inflammatory Arthritis: Results From the Norfolk Arthritis RegisterRyan M. Hum, Seema D. Sharma, Michael Stadler, Sebastien Viatte, Pauline Ho, Nisha Nair, Chenfu Shi, Chuan Fu Yap, Mehreen Soomro, Darren Plant, Jenny H. Humphreys, Alexander MacGregor, Max Yates, Suzanne Verstappen, Anne Barton, John Bowes, on behalf of all NOAR collaboratorsdoi: 10.1002/art.42760 | Arthritis & Rheumatology, Vol. 76, No. 5, May 2024, pp. 696-703
- Metabolomic and lipidomic fingerprints in inflammatory skin diseases – Systemic illumination of atopic dermatitis, hidradenitis suppurativa and plaque psoriasisS. Rischke, S.M.G. Schäfer, A. König, T. Ickelsheimer, M. Köhm, L. Hahnefeld, A. Zaliani, K. Scholich, A. Pinter, G. Geisslinger, F. Behrens, R. Gurkedoi: 10.1016/j.clim.2024.110305 | Clinical Immunology 265 (2024) 110305. 5 July 2024
2023
- DeepNAPSI multi-reader nail psoriasis prediction using deep learningLukas Folle, Pauline Fenzl, Filippo Fagni , Mareike Thies, Vincent Christlein, Christine Meder , David Simon , Ioanna Minnopoulou , Michael Sticherling , Georg Schett , Andreas Maier, Arnd Kleyerdoi: 10.1038/s41598-023-32440-8 | Scientific Reports volume 13, Article number: 5329 (2023)
- Pre-analytical sample handling standardization for reliable measurement of metabolites and lipids in LC-MS-based clinical researchA. Sens, S. Rischke, L. Hahnefeld, E. Dorochow, S.M.G. Schäfer, D. Thomas, M. Köhm, G. Geisslinger, F. Behrens, R. Gurkedoi: 10.1016/j.jmsacl.2023.02.002 | Journal of Mass Spectrometry and Advances in the Clinical Lab, Volume 28, April 2023, Pages 35-46
- Small molecule biomarker discovery: Proposed workflow for LC-MS-based clinical research projectsS. Rischke, L. Hahnefeld, B. Burla, F. Behrens, R. Gurke, T.J. Garrettdoi: 10.1016/j.jmsacl.2023.02.003 | Journal of Mass Spectrometry and Advances in the Clinical Lab, Volume 28, April 2023, Pages 47-55
- Non-invasive metabolic profiling of inflammation in joints and entheses by multispectral optoacoustic tomographyTascilar K, Fagni F, Kleyer A, Bayat S, Heidemann R, Steiger F, Krönke G, Bohr D, Ramming A, Hartmann F, Klett D, Federle A, Regensburger AP, Wagner AL, Knieling F, Neurath MF, Schett G, Waldner M, Simon D.doi: 10.1093/rheumatology/keac346 | Rheumatology, Volume 62, Issue 2, February 2023, Pages 841–849
- Tolerability of low to moderate biomechanical stress during leisure sport activity in patients with psoriasis and psoriatic arthritisFilippo Fagni, Melek Yalcin Mutlu, Selahattin Alp Temiz, Ioanna Minopoulou, Manuel Krieter, Georg Schett, Arnd Kleyer, David Simon and Axel J Hueberdoi: 10.1136/rmdopen-2023-003612 | RMD Open 2023;9:e003612. doi:10.1136/ rmdopen-2023-003612. December 1, 2023
- Application of clinical and molecular profiling data to improve patient outcomes in psoriatic arthritisOliver FitzGerald, Frank Behrens, Anne Barton, Heidi Bertheussen, Bruno Boutouyrie-Dumont, Laura Coates, Owen Davies, Maarten de Wit, Filippo Fagni, Carl S Goodyear, Robert Gurke, Lisa Hahnfeld, Christine Huppertz, Vassilios Ioannidis, Mark Ibberson, Arnon Katz, Maximilian Klippstein, Michaela Koehm, Shimon Korish, Sina Mackay, David A. Martin, Denis O'Sullivan, Khadijah Patel, Stefan Rueping, Georg Schett, Klaus Scholich, Jochen M. Schwenk, Stefan Siebet, David Simon, Arani Vivekanantham and Stephen R Penningtondoi: 10.1177/1759720X231192315 | Therapeutic Advances in Musculoskeletal Disease, Volume 15, January-December 2023. September 8, 2023.
Plain language summary
Improving outcomes in Psoriatic Arthritis
Psoriatic Arthritis (PsA) is a form of arthritis which is found in approximately 30% of people who have the skin condition, Psoriasis. Frequently debilitating and progressive, achieving a good outcome for a person with PsA is made difficult by late diagnosis, disease clinical features and in many cases, failure to adequately control features of inflammation. Research studies from individual centres have certainly contributed to our understanding of why people develop PsA but to adequately address the major areas of unmet need, multi-centre, collaborative research programmes are now required. HIPPOCRATES is a 5-year, Innovative Medicines Initiative (IMI) programme which includes 17 European academic centres experienced in PsA research, 5 pharmaceutical industry partners, 3 small-/medium-sized industry partners and 2 patient representative organisations (see appendix). In this review, the ambitious programme of work to be undertaken by HIPPOCRATES is outlined and common approaches and challenges are identified. The participation of patient research partners in all stages of the work of HIPPOCRATES is highlighted. It is expected that, when completed, the results will ultimately allow for changes in the approaches to diagnosing, managing and treating PsA allowing for improvements in short-term and long-term outcomes.
- Machine learning identifies right index finger tenderness as key signal of DAS28-CRP based psoriatic arthritis activitySamuel Rischke, Sorwe Mojtahed Poor, Robert Gurke, Lisa Hahnefeld, Michaela Köhm, Alfred Ultsch, Gerd Geisslinger, Frank Behrens, and Jörn Lötschdoi: 10.1038/s41598-023-49574-4 | Sci Rep 13, 22710 (2023). 19 December 2023
- ALISTER - Application for lipid stability evaluation and researchSamuel Rischke, Robert Gurke, Alexandre Bennett, Frank Behrens, Gerd Geisslinger, Lisa Hahnefelddoi: 10.1016/j.cca.2024.117858 | Clinica Chimica Acta, Volume 557, 15 April 2024
- Gut Inflammation in Axial Spondyloarthritis Patients is Characterized by a Marked Type 17 Skewed Mucosal Innate-like T Cell SignatureCéline Mortier, Katrien Quintelier, Ann-Sophie De Craemer, Thomas Renson, Liselotte Deroo, Emilie Dumas, Eveline Verheugen, Julie Coudenys, Tine Decruy, Zuzanna Lukasik, Sofie Van Gassen, Yvan Saeys, Anne Hoorens, Triana Lobaton, Filip Van den Bosch, Tom Van de Wiele, Koen Venken, and Dirk Elewautdoi: 10.1002/art.42627(2023) ARTHRITIS & RHEUMATOLOGY. 75(11). p.1969-1982. 09 June 2023
2022
- OMICS and multi‐OMICS analysis for the early identification and improved outcome of patients with psoriatic arthritisRobert Gurke, Annika Bendes, John Bowes, Michaela Koehm, Richard M Twyman, Anne Barton, Carl Goodyear, Lisa Hahnefeld, Rainer Hillenbrand, Ewan Hunter, Mark Ibberson, Vassilios Ioannidis, Sabine Kugler, Eduard Resch, Stefan Rüping, Klaus Scholich, Jochen M Schwenk, James C Waddington, Phil Whitfield, Gerd Geißlinger, Oliver FitzGerald, Frank Behrens, and Stephen Pennington on behalf of the HIPPOCRATES consortiumdoi: 10.3390/biomedicines10102387 | Biomedicines 2022, 10(10), 2387 (September 2022)
- Effects of casirivimab/imdevimab on systemic and mucosal immunity against SARS-CoV-2 in B-cell depleted patients with autoimmune rheumatic diseases refractory to vaccinationFilippo Fagni, Katja Schmidt, Daniela Bohr, Larissa Valor-Méndez, Fabian Hartmann, Koray Tascilar, Karin Manger, Bernhard Manger, Arnd Kleyer, David Simon, Georg Schett and Thomas Harrerdoi: 10.1136/rmdopen-2022-002323 | RMD Open 2022;8:e002323 (May 2022)
- Concise report: a minimal-invasive method to retrieve and identify entheseal tissue from psoriatic arthritis patientsMilena L Pachowsky, Maria Gabriella Raimondo, Cong Xu, Simon Rauber, Koray Tascilar, Hannah Labinsky, Mario Vogg, Mina Saad Aziz Saad, David Simon, Juergen Rech, Alina Soare, Lars Braeuer, Arnd Kleyer, Georg Schett, Andreas Rammingdoi: 10.1136/annrheumdis-2021-222061 | Annals of the Rheumatic Diseases | Published Online First: 22 April 2022.
- Advanced neural networks for classification of MRI in psoriatic arthritis, seronegative, and seropositive rheumatoid arthritisLukas Folle, Sara Bayat, Arnd Kleyer, Filippo Fagni, Lorenz A Kapsner, Maja Schlereth, Timo Meinderink, Katharina Breininger, Koray Tacilar, Gerhard Krönke, Michael Uder, Michael Sticherling , Sebastian Bickelhaupt, Georg Schett, Andreas Maier, Frank Roemer, David Simondoi: 10.1093/rheumatology/keac197 | Rheumatology (Oxford). 2022 Mar 25:keac197 | Epub ahead of print. PMID: 35333316.
- Characterization of Serum and Mucosal SARS-CoV-2-Antibodies in HIV-1-Infected Subjects after BNT162b2 mRNA Vaccination or SARS-CoV-2 InfectionSchmidt KG, Harrer EG, Tascilar K, Kübel S, El Kenz B, Hartmann F, Simon D, Schett G, Nganou-Makamdop K, Harrer T.doi: 10.3390/v14030651 | Viruses 2022, 14(3), 651 (March 2022)
- Deep Learning-Based Classification of Inflammatory Arthritis by Identification of Joint Shape Patterns-How Neural Networks Can Tell Us Where to "Deep Dive" Clinically.Lukas Folle; David Simon; Koray Tascilar; Gerhard Krönke; Anna-Maria Liphardt; Andreas Maier; Georg Schett; Arnd Kleyerdoi: 10.3389/fmed.2022.850552 | Front. Med., 10 March 2022 Sec. Rheumatology Volume 9 - 2022 (March 2022)
- HIPPOCRATES: improving diagnosis and outcomes in psoriatic arthritisOliver Fitz Gerald, Stephen R Penningtondoi: 10.1038/s41584-022-00748-w | Nat Rev Rheumatol 18, 123–124 (2022) | Published: 27 January 2022
- Sequential interleukin-17/interleukin-23 inhibition in treatment-refractory psoriatic arthritisDavid Simon, Filippo Fagni, Georg Schettdoi: 10.1136/annrheumdis-2022-222415 | Annals of the Rheumatic Diseases 2022;81:1334-1336
2021
- Impact of Cytokine Inhibitor Therapy on the Prevalence, Seroconversion Rate, and Longevity of the Humoral Immune Response Against SARS?CoV-2 in an Unvaccinated CohortDavid Simon, Koray Tascilar, Arnd Kleyer, Filippo Fagni, Gerhard Krönke, Christine Meder, Peter Dietrich, Till Orlemann, Thorsten Kliem, Johanna Mößner, Anna-Maria Liphardt, Verena Schönau, Daniela Bohr, Louis Schuster, Fabian Hartmann, Moritz Leppkes, Andreas Ramming, Milena Pachowsky, Florian Schuch, Monika Ronneberger, Stefan Kleinert, Axel J. Hueber, Karin Manger, Bernhard Manger, Raja Atreya, Carola Berking, Michael Sticherling, Markus F. Neurath, Georg Schettdoi: 10.1002/art.42035 | Arthritis Rheumatol . 2022 May;74(5):783-790 (December 2021)